THE EFFECT OF BZ 55 ON THE PANCREATIC ISLETS

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Abstract
A single injection of 500 mg/kg of BZ 55 (carbutamide) caused a decrease in the blood sugar level and degranulation of the [beta]-cells of the pancreatic islets in rats. Daily administration of the same amount of BZ 55 caused a gradual increase in the fasting blood sugar. After several weeks, a diabetic level was reached and at the same time the [beta]-cells were found to be degranulated. Daily treatment for about 6 weeks with 1/4 the amount of alloxan which causes acute diabetes or 10 mg/kg also caused development of a diabetic blood sugar level and degranulation of the [beta]-cells. It is suggested that BZ 55 causes a release of the insulin content of the [beta]-cells.