Effect of Hyaluronidase on the Subcutaneous Absorption of Electrolytes in Humans

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Abstract
In order to study the effect of hyaluronidase on the subcutaneous absorption of electrolytes in humans, expts. were carried out with 0.9% NaCl containing radiosodium (Na24). Observations were made on the rate of disappearance of Na24 from the injn. site by means of an externally placed Geiger counter, and on the serum Na24 concn. following subcut. injn. Although considerable variation was observed in any given subject, the addition of hyaluronidase hastened the disappearance of Na24 from the injn. site. Results also indicated that Na24 enters the blood from subcut. tissues more rapidly under the influence of hyaluronidase.