Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia
- 11 February 2005
- journal article
- research article
- Published by Elsevier in Neurobiology of Disease
- Vol. 18 (3) , 638-648
- https://doi.org/10.1016/j.nbd.2004.10.016
Abstract
No abstract availableKeywords
This publication has 43 references indexed in Scilit:
- γ-Secretase Activity of Presenilin 1 Regulates Acetylcholine Muscarinic Receptor-mediated Signal TransductionPublished by Elsevier ,2004
- Enhanced generation of intracellular Aβ42 amyloid peptide by mutation of presenilins PS1 and PS2European Journal of Neuroscience, 2004
- Dysregulated IP3Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation inPresenilin1Results in Exaggerated Ca2+Signals and Altered Membrane ExcitabilityJournal of Neuroscience, 2004
- Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase ActivitiesJournal of Biological Chemistry, 2003
- BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for ApoptosisScience, 2003
- Capacitive Calcium Entry Is Directly Attenuated by Mutant Presenilin-1, Independent of the Expression of the Amyloid Precursor ProteinJournal of Biological Chemistry, 2003
- High Prevalence of Pathogenic Mutations in Patients with Early-Onset Dementia Detected by Sequence Analyses of Four Different GenesAmerican Journal of Human Genetics, 2000
- Calcium Responses in Fibroblasts from Asymptomatic Members of Alzheimer's Disease FamiliesNeurobiology of Disease, 1998
- Disturbances of the neuronal calcium homeostasis in the aging nervous systemLife Sciences, 1994
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991