INFLUENCE OF GROWTH AND ADRENOCORTICOTROPIC HORMONES ON THE BODY COMPOSITION OF HYPOPHYSECTOMIZED RATS1

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Abstract
A. the influence of growth hormone The changes in the body composition of animals after treatment with pituitary growth extracts have been studied by several investigators. Both Downs (1930) and Wadehn (1932) obtained accelerated growth in mice with a pituitary preparation and found that the treated animals contained more water and protein but less fat than did the controls. Bierring and Nielsen (1932) induced increase in body weight in rats by an alkaline anterior pituitary extract and showed that the body weight increment was not entirely due to retention of water. Using the pair-fed technique, Lee and Schaffer (1934) conclusively demonstrated that the growth in rats caused by injection of pituitary growth extract is chiefly due to increase in the protein and water content and that there is a decrease in fat. Recent studies of Young 1945) have confirmed these findings.