Glucocorticoids in Adrenocortical Carcinoma of Mice

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Abstract
Adrenocortical carcinomas, induced in mice by early castration and transplanted to recipient mice, were assayed for glucocorticoids by the mouse liver glycogen method of Venning. Glucocorticoids were present in all tumors, but the content was lower than that of normal mouse adrenals on a tissue wt. basis. Incubation of tumor homogenate with desoxycorticosterone glucoside failed to yield increased glucogenic activity.