Plasma Bupivacaine Concentrations in Children during Caudal Epidural Analgesia
Open Access
- 1 February 1983
- journal article
- research article
- Published by SAGE Publications in Anaesthesia and Intensive Care
- Vol. 11 (1) , 20-22
- https://doi.org/10.1177/0310057x8301100104
Abstract
Plasma bupivacaine concentrations were measured in 45 children, whose ages ranged from 4 months to 12 years, following administration of caudal epidural analgesia. Using 3 mg/kg of bupivacaine 0.25%, mean blood levels of 1.2-1.4 μg/ml were reached, which are well within the limits of projected toxic levels. Simultaneous arterial and venous sampling showed a small but significant difference between these two sampling sites for the first fifteen minutes.Keywords
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