THE SOURCE OF THE BLOOD ACETONE RESULTING FROM THE ADMINISTRATION OF THE KETOGENIC PRINCIPLE OF THE ANTERIOR HYPOPHYSIS

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Abstract
A neutralized alkaline extract of the anterior hypophysis was administered to normal and eviscerated rabbits. This extract produced a rise in the acetone body content of the blood of the normal rabbits but was ineffective in the eviscerated rabbits. The ketogenic principle of the anterior hypophysis apparently acts solely in the presence of the liver and the extrahepatic tissues do not contribute to the resulting ketosis. An hypothesis is presented which attributes the production of ketone bodies to a relative decrease of carbohydrate utilization by the liver in the presence of an increased catabolism of fatty acids consequent to an accelerated hepatic glycogenolysis.

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