ACTIVATION OF CAMP-DEPENDENT PROTEIN-KINASE WITHOUT A CORRESPONDING INCREASE IN PHOSPHORYLASE ACTIVITY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (2) , 283-290
Abstract
The effect of prostaglandin E1(PGE1) and epinephrine on glycogen metabolism was investigated in the perfused rat heart. Both agents produced increases in c[cyclic]AMP and the cAMP-dependent protein kinase activity ratio. When dosages were adjusted to give equal increases in the protein kinase activity ratio from a basal value of 0.15 to as high as 0.40, only epinephrine caused a significant increase in phosphorylase activity. When used together, PGE1 did not effect the ability of epinephrine to increase phosphorylase activity.

This publication has 1 reference indexed in Scilit: