A Dysbalanced Immune System in Cryptogenic Lennox‐Gastaut Syndrome

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Abstract
In children with cryptogenic Lennox‐Gastaut syndrome we found a functionally impaired humoral immune response to a primary antigen (haemocyanin), despite signs of a triggered immune system consisting of elevated IgG concentrations. This combination of immunological findings, considered to be the expression of a dysbalanced‐triggered as well as functionally impaired‐immune system, has also been described in an auto‐immune disease like systemic lupus erythaematodes in humans, and in genetically epilepsy‐prone rats. The interactions between the immune system and the nervous system in Lennox‐Gastaut syndrome will be discussed.