Variably occlusive tape systems and the mitotic activity of stripped human epidermis. Effects with and without hydrocortisone

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Abstract
This study elaborates on the effect of occlusive, partially occlusive and nonocclusive tape systems containing hydrocortisone on human epidermal mitotic activity that was increased by tape stripping. The experimental variables included tape delivery sytems affording total, partial (50%), or no occlusion to normal human skin. The test corticosteroid was hydrocortisone at a dose range of 1, 4 and 20 .mu.g/cm2. Utilizing demecolcine cream, biopsy specimens were taken and mitotic figures determined. Potent antimitotic effects occur equally with semiocclusive and nonocclusive tapes containing hydrocortisone as with total occlusive tapes. Verification of the practicality of this in clinical use will depend on appropriate clinical trials in diseased states.