Autoradiographic localisation of VIP receptors in human lung
- 21 April 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 199 (2) , 198-202
- https://doi.org/10.1016/0014-5793(86)80479-3
Abstract
Localisation and pharmacological properties of the VIP receptor in human lung sections are described. The receptor density determined by saturation analysis using 125I‐VIP is approx. 100 protein, with a k d of approx. 600 pM. Inhibition of 125I‐VIP binding with VIP and related peptides gives a rank order of potency: VIP /s> peptide histidine methionine /s> secretin. Light microscope autoradiography reveals specific VIP binding sites, with a high density over the pulmonary artery smooth muscle and the alveolar walls and with a lower density over the bronchial epithelium.Keywords
This publication has 14 references indexed in Scilit:
- Characterisation of a high-affinity VIP receptor in human lung parenchymaFEBS Letters, 1986
- VIP like immunoreactive nerves in human respiratory tractHistochemistry and Cell Biology, 1985
- Characterization and Localization of Vasoactive Intestinal Peptide Receptors in the Rat LungEndocrinology, 1984
- VIP AS BRONCHODILATORThe Lancet, 1984
- Effects of PHI on vasoactive intestinal peptide receptors and adenylate cyclase activity in lung membranes. A comparison in man, rat, mouse and guinea pigRegulatory Peptides, 1982
- Comparison of VIP-secretin receptors in rat and human lungPeptides, 1981
- Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cats, and human subjectsCell and tissue research, 1981
- A new method for receptor autoradiography: [3H]Opioid receptors in rat brainBrain Research, 1979
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949