Neonatally Induced Tolerance to HGG: Duration in B Cells and Absence of Specific Suppressor Cells
Open Access
- 1 July 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 119 (1) , 311-314
- https://doi.org/10.4049/jimmunol.119.1.311
Abstract
A specific, long lasting, tolerant state to human γ-globulin (HGG) was established in neonatal A/J mice. These suckling mice received the tolerogen in the colostrum of their mother who had been injected with DHGG. The tolerant state could not be accounted for by “factors” other than HGG in the colostrum. The duration of this tolerance in the intact animal and in the B cell population was 16 to 18 weeks. Naturally occuring nonspecific suppressor cells were evident but specific suppressor cells could not be demonstrated. These results are discussed in relation to possible mechanisms of the induction of tolerance to self.This publication has 4 references indexed in Scilit:
- Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.The Journal of Experimental Medicine, 1976
- In vitro tolerance induction of neonatal murine B cells.The Journal of Experimental Medicine, 1976
- B-LYMPHOCYTE DIFFERENTIATION INDUCED BY LIPOPOLYSACCHARIDE .3. SUPPRESSION OF B CELL MATURATION BY ANTI-MOUSE IMMUNOGLOBULIN ANTIBODIES1976
- SPECIFIC SUPPRESSION OF IMMUNE-RESPONSE BY HGG TOLERANT SPLEEN-CELLS .1. PARAMETERS AFFECTING LEVEL OF SUPPRESSION1976