THE- INFLUENCE OF ESTROGEN UPON GOITER INDUCTION IN ADULT AND IMMATURE RATS

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Abstract
THERE have been many conflicting reports as to the way in which the thyroid glands of experimental animals are affected, if at all, by the administration of estrogenic hormones. The subject has been carefully reviewed by Noach (1, 2). In adult, propylthiouraciP-treated rats, we have found that the concurrent administration of an estrogen, a-estradiol benzoate2, reduces the hyperplastic response of the thyroid gland to the goitrogen. The present report deals with this inhibitory phenomenon, and with the effects thereon of age, sex, strain and variations in drug dosage. MATERIALS AND METHODS A total of 281 male and female rats (from 20 days to 10 months-in-age) of the Vanderbilt, Sprague-Dawley, and Wistar strains was used in this study. Batches of animals of the same strain, sex, age and approximate weight were divided into the various experimental and control groups for each run, and kept under identical conditions, except for the variations in drug administration.

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