Hemopoietic progenitor cell function after hla‐identical sibling bone marrow transplantation: Influence of chronic graft‐versus‐host disease

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Abstract
We examined hemopoietic reconstitution during the first 12 months post‐transplant in 31 patients given high‐dose cyclophosphamide, total body irradiation and an HLA‐identical sibling marrow transplant for hematological malignancy. Unexpectedly, we found marrow CFU‐gm and marrow CFU‐e cells to be denser than normal throughout the first year post‐transplant. While functionally adequate neutrophil and platelet counts were achieved in the first six weeks post‐transplant, there were defects in hemopoietic progenitor cell function during the first year post‐transplant. Although we could detect no influence from acute graft‐versus‐host disease (GVHD), chronic GVHD adversely affected the growth of both myeloid and erythroid blood progenitor cells.