Hydralazine and furosemide kinetics

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Abstract
Furosemide kinetics were studied in 25 patients with congestive heart failure. The elimination half-life (t 1/2) was longer and the elimination rate constant and the plasma clearance smaller in patients with advanced (n = 15) than in those with moderate (n = 10) failure. Furosemide kinetics with and without hydralazine were compared in 8 patients with advanced heart failure. Furosemide t 1/2 in patients receiving both drugs fell from 96 .+-. 16 to 81 .+-. 15 min (P < 0.02), elimination rate constant increased from 0.0186 .+-. 0.0056 to 0.0214 .+-. 0.0068 min-1 (P < 0.05), and plasma clearance rose from 72.6 .+-. 18.5 to 88.1 .+-. 26.9 ml/min (P < 0.01). Renal clearance rose from 45.4 .+-. 12.0 to 60.9 .+-. 19.0 ml/min (P < 0.01) and creatinine clearance was unchanged. Apparently, hydralazine affects furosemide kinetics.

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