ELEVATED ACTIVITY OF INTERLEUKINS-1, -2 AND -3 IN THE BONE MARROW OF COLLAGEN-INDUCED ARTHRITIC RATS

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Abstract
The interleukin (IL)-1, -2 and -3 activity was elevated in the bone marrow of rats with collagen-induced arthritis. Two weeks after immunization of rats with type II collagen, a marked elevation of IL-1, -2 and -3 was observed in rats with arthritis, while no significant elevation of IL-2 was observed in rats without arthritis. Three months after the treatment, the activity of IL-1 and -3, was still high, whereas the activity of IL-2 was considerably lowered in animals with chronic arthritis. In control rats without the treatment, there was no elevation of these cytokines. Two weeks after the collagen treatment, undifferentiated cells and acute inflammatory cells were seen to accumulate in the bone marrow of the distal tibia, where the cell components are scarcely found in control animals. In addition to these cells, chronic inflammatory cells were also seen 3 months after immunization.