Comparison of Therapeutic Efficacies of Type A and F Botulinum Toxins for Blepharospasm
- 1 March 1995
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Neurology
- Vol. 45 (3) , 506-508
- https://doi.org/10.1212/wnl.45.3.506
Abstract
Article abstract-Type F botulinum toxin can be used for treating patients with dystonia who become refractory to type A toxin injection due to antibody development. We compared the therapeutic efficacy of type F botulinum toxin to that of type A toxin in a self-controlled, double-blind clinical trial. In nine patients with blepharospasm, we injected type A toxin on one side and the same units of type F toxin on the other side. Although the onset of clinical effect, maximal benefit, and adverse reactions were similar between type A and F toxins, the duration of the clinical effect was significantly shorter on the side injected with type F toxin. Although type F toxin proved its promise as an alternative to type A toxin, its usefulness is limited by the shorter duration of action. NEUROLOGY 1995;45: 506-508Keywords
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