In situ hybridization and translocation breakpoint mapping
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 39 (3) , 179-183
- https://doi.org/10.1159/000132131
Abstract
We have performed in situ hybridization of a probe for the λ IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-related chromosomal rearrangements with breakpoints in 22q11. In this study we have demonstrated that the breakpoints are proximal to the λ IGLC constant region cluster. Thus, at the molecular level, DGS-related breakpoints can be distinguished from the 22q11 breakpoint of CML, but not from the 8;22 translocation of Burkitt lymphoma or from the 21;22 translocations that we have previously studied.Keywords
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