In situ hybridization and translocation breakpoint mapping
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 38 (2) , 127-131
- https://doi.org/10.1159/000132044
Abstract
In situ chromosomal hybridization of a probe for part of the lamda light chain constant region (Cλ) has demonstrated that the 22q11 breakpoints of chronic myelogenous leukemia (CML) t(9;22) and Burkitt lymphoma t(8;22) are not identical. For CML, the breakpoint is distal to the IGLC genes, whereas for Burkitt lymphoma it is proximal. The study provides direct evidence for regional assignment of the IGLC gene cluster to 22q11.Keywords
This publication has 2 references indexed in Scilit:
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- The association of the DiGeorge anomalad with partial monosomy of chromosome 22The Journal of Pediatrics, 1982