Application of a non-indexed dual sprayer pneumatically assisted electrospray source to the high throughput quantitation of target compounds in biological fluids
- 6 October 2000
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 14 (21) , 2034-2038
- https://doi.org/10.1002/1097-0231(20001115)14:21<2034::aid-rcm124>3.0.co;2-6
Abstract
The need for increased throughput in the quantitation of target compounds in biological fluids by high performance liquid chromatography/mass spectrometry continues to drive research in this area. This report describes the application of a prototype dual sprayer electrospray source for the quantitative analysis of biological samples. Quantitative performance for 180 compounds in a microsomal stability assay was found to be adequate when compared with a conventional single sprayer measurement. Issues with use of dual sprayers in a routine production environment are discussed. Copyright © 2000 John Wiley & Sons, Ltd.Keywords
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