VAGINAL EPITHELIAL CHANGES IN YOUNG-WOMEN ENROLLED IN THE NATIONAL-COOPERATIVE-DIETHYLSTILBESTROL-ADENOSIS-(DESAD)-PROJECT

  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (3) , 300-308
Abstract
Initial clinical findings are reported for the 3339 young women enrolled in the Diethylstilbestrol Adenosis project. Changes in the vaginal mucosa (VEC-vaginal epithelial changes), which were detected by colposcopy or I staining, occurred in 34% of 1275 participants identified by review of prenatal records, 59% of participants who themselves requested entry into the project and 65% of participants referred by a physician. Analysis of data on the 298 women who were identified by record review and whose prenatal records contained complete information about drug exposure indicated that VEC is most closely associated with the timing of the onset of intrauterine exposure to diethylstilbestrol (DES), total dose and length of exposure. Frequency of VEC decreased with age. No instances of severe dysplasia,carcinoma in situ, invasive squamous cell adenocarcinoma or clear cell carcinoma were observed among the women identified by record review.