Effect of Cytochrome C Therapy on Altitude Tolerance of Normal Rats

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Abstract
The effect of cytochrome C upon the ability of rats to withstand high altitude exposure was studied by comparing the survival rates of animals given an intraperitoneal injn. of 5 mg. in isotonic saline with those of control animals treated with a similar amt. of saline. Groups of control and exptl. animals were exposed simultaneously for periods of 1 hr. at altitudes of 33,000 and 35,000 ft. In both instances, the survival rate was higher in the control groups, the mean values being 15% for the treated group and 45% for the control group. The cytochrome C is, therefore, considered ineffective in alleviating the anoxia of high altitude exposure.