Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic adenosine monophosphate accumulation in human platelets
- 30 April 1980
- journal article
- research article
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 27 (5) , 607-611
- https://doi.org/10.1038/clpt.1980.86
Abstract
The effect of acute methadone withdrawal was studied on PGE1(prostaglandin E1)-sensitive platelet adenylate cyclase of 8 former heroin addicts who were stabilized with methadone. During acute methadone withdrawal there was a significant increase in PGE1-sensitive platelet adenylate cyclase activity, which correlated with the severity of withdrawal symptoms. Apparently PGE1-sensitive adenylate cyclase and cAMP are involved in the human addictive process.This publication has 2 references indexed in Scilit:
- Cerebellar cAMP levels following acute and chronic morphine administrationCanadian Journal of Physiology and Pharmacology, 1977
- EFFECT OF NARCOTIC DEPENDENCE AND WITHDRAWAL ON STRIATAL DOPAMINE-SENSITIVE ADENYLATE-CYCLASE AND SYNAPTOSOMAL CYCLIC-AMP METABOLISM1976