A STUDY OF VITAMIN A DEFICIENCY IN NORMAL AND DEPANCREATIZED DOGS

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Abstract
On a diet of raw meat, cracker meal, raw pancreas and Vitamins B, G and D, 9 depancreatized dogs developed loss of hair, scaliness of the skin, sores and a discharge from the eyes[long dash]symptoms not overcome by feeding carotene or cod liver oil concentrate. The livers, examined for their vitamin A content by the Carr and Price modification of the SbCl3 test, were very low in vitamin A. Well-fed laboratory dogs had a very high vitamin A content in their livers. In 2 intact devita-minized dogs, feeding of carotene overcame the symptoms; the vitamin content in their livers was fairly high when they were killed. Hence it is suggested that the depancreatized dog is unable to utilize vitamin A owing either to a drainage of the vitamin from the liver or possibly to a disturbance of the fat metabolism.

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