Imaging endogenous dopamine competition with [11C]raclopride in the human brain
- 1 April 1994
- Vol. 16 (4) , 255-262
- https://doi.org/10.1002/syn.890160402
Abstract
This study images dopamine release in response to a neurochemically specific challenge with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by methylphenidate were evaluated with positron emission tomography and [11C]raclopride, a D2 receptor radioligand that is sensitive to endogenous dopamine. Methylphenidate significantly decreased striatal [11C]raclopride binding. The decrease was variable and was negatively correlated with age. Mood and anxiety at baseline, were also correlated with methylphenidate‐induced DA changes. This strategy provides a tool to investigate the responsiveness of the dopamine system in the normal and diseased human brain and to investigate the neurochemical correlates of behavior.Keywords
This publication has 58 references indexed in Scilit:
- Does impaired primacy recall equal impaired long‐term storage?: Serial position effects in Huntington's disease and Alzheimer's diseaseDevelopmental Neuropsychology, 1993
- Quantitation of Carbon‐11‐labeled raclopride in rat striatum using positron emission tomographySynapse, 1992
- In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine‐123 labeled RTI‐55Synapse, 1992
- Amphetamine induced decreases in (18F)‐N‐methylspiroperidol binding in the baboon brain using positron emission tomography (PET)Synapse, 1991
- Nomifensine‐induced increased in extracellular striatal dopamine is enhanced by isoflurane anaesthesiaSynapse, 1991
- Difference in in vivo receptor binding between [3 H]N-methylspiperone and [3 H]raclopride in reserpine-treated mouse brainJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1991
- Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitroLife Sciences, 1990
- In vivo binding of [18F]GBR 13119 to the brain dopamine uptake systemLife Sciences, 1988
- Time course of nigrostriatal degeneration in parkinson's diseaseJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1976
- Antipsychotic drug doses and neuroleptic/dopamine receptorsNature, 1976