BIAS OF THE CONTRIBUTION OF SINGLE-LOCUS EFFECTS TO THE VARIANCE OF A QUANTITATIVE TRAIT
- 1 July 1986
- journal article
- research article
- Vol. 39 (1) , 137-144
Abstract
Advances in our understanding of the physiology of many quantitative phenotypes combined with better measurement abilities is providing a means for pursuing a measured genotype approach to partitioning the phenotypic variance into the contribution of separate loci. The standard estimate of the contribution of a single locus to the phenotypic variance applied recently in the human genetics literature is a biased statistic. We compare the biased estimates from several published studies with biased corrected estimates to illustrate the general problem.This publication has 15 references indexed in Scilit:
- The use of measured genotype information in the analysis of quantitative phenotypes in manAnnals of Human Genetics, 1986
- HOW MUCH OF VARIABILITY IN APOLIPOPROTEIN AII CONCENTRATIONS IS EXPLAINED BY POLYMORPHISM ADJACENT TO APO-AII GENE?The Lancet, 1985
- ROLE OF THE APOLIPOPROTEIN-E POLYMORPHISM IN DETERMINING NORMAL PLASMA-LIPID AND LIPOPROTEIN VARIATION1985
- The analysis of intraclass correlation in multiple samplesAnnals of Human Genetics, 1985
- Apolipoprotein E polymorphism and coronary artery disease.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1983
- GENETIC ANALYSIS OF SYSTOLIC BLOOD PRESSURE IN MELBOURNE FAMILIESClinical and Experimental Pharmacology and Physiology, 1982
- APPLICATION OF LOD METHOD TO DETECTION OF LINKAGE BETWEEN A QUANTITATIVE TRAIT AND A QUALITATIVE MARKER - SIMULATION EXPERIMENT1976
- Studies on blood and urine glucose in Seminole Indians: indications for segregation of a major gene.1974
- The use of biochemical data in screening for mutant alleles and in genetic counselling*Annals of Human Genetics, 1974
- Common polymorphism of Peptidase A. Electrophoretic variants associated with quantitative variation of red cell levelsAnnals of Human Genetics, 1973