Increased Expression of Bone Sialoprotein in Bone Metastases Compared with Visceral Metastases in Human Breast and Prostate Cancers
Open Access
- 1 May 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 15 (5) , 834-843
- https://doi.org/10.1359/jbmr.2000.15.5.834
Abstract
The recent demonstration that bone sialoprotein (BSP) is expressed in osteotropic cancers suggests that this bone matrix protein might be implicated in the preferential seed and growth of metastatic cells in bone. High expression of BSP in breast and prostate primary carcinomas is associated with progression and bone metastases development. The exact mechanisms by which BSP may favor bone metastases formation are not clearly established yet. Although BSP expression has been detected in breast, prostate, lung, thyroid, and neuroblastoma primary tumors, no information regarding its expression in metastases is available to date. In this study, we have examined BSP expression in 15 bone and 39 visceral metastatic lesions harvested from 8 breast cancer patients and 7 prostate cancer patients who died of disseminated disease. We were able to retrieve the primary lesions from 5 of the 8 breast cancer patients as well as from all 7 prostate cancer patients. All the primary breast tumor patients and 5 of the 7 primary prostate cancer patients expressed a detectable level of BSP. Bone metastases from all 8 breast cancer patients and from 5 out of 7 prostate cancer patients exhibited detectable levels of the protein. Metastatic cells in close contact with bone trabeculae usually were highly positive for BSP. BSP also was detected in secondary lesions developed at visceral sites including liver, thyroid, lung, and adrenal glands. However, BSP expression was significantly lower in visceral metastases than in skeletal ones (Mann-Whitney test, p < 0.05). Our data represent the first demonstration of an increased expression of BSP in bone metastases compared with nonskeletal metastases in human breast and prostate cancers and add weight to the body of evidence attributing a significant role to this protein in the genesis of bone metastases. (J Bone Miner Res 2000;15:834–843)Keywords
This publication has 35 references indexed in Scilit:
- Integrin αvβ3 Expression by Bone-residing Breast Cancer MetastasesDiagnostic Molecular Pathology, 1996
- Bone sialoprotein expression in primary human breast cancer is associated with bone metastases developmentJournal of Bone and Mineral Research, 1996
- Interaction of Osteopontin with Osteoclast IntegrinsaAnnals of the New York Academy of Sciences, 1995
- Are cellular adhesion molecules involved in the metastasis of breast cancer?Breast Cancer Research and Treatment, 1994
- Distribution of noncollagenous proteins in the matrix of adult human bone: Evidence of anatomic and functional heterogeneityJournal of Bone and Mineral Research, 1993
- Purification and fragmentation of nondenatured bone sialoprotein: Evidence for a cryptic, RGD-resistant cell attachment domainJournal of Bone and Mineral Research, 1993
- The TNM classification of prostate cancerThe Prostate, 1992
- The Cellular Basis of Site-Specific Tumor MetastasisNew England Journal of Medicine, 1990
- Skeletal MetastasesClinical Orthopaedics and Related Research, 1986
- THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.The Lancet, 1889