Acquisition of tolerance to the antiproliferative activity of interferon by X-ray transformed C3H/10T1/2 cells under prolonged treatment with interferon

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Abstract
X‐ray‐transformed C3H/10T1/2 cells serially passaged in the presence of highly purified mouse interferon appeared to acquire progressively a tolerance to the inhibitory effect of interferon on cell proliferation. In contrast, these cells did not appear to develop a tolerance to the antiviral activity of interferon. These results suggest the possibility that these two effects of interferon are mediated by different mechanisms.