Pharmacokinetics of sufentanil in general surgical patients under different conditions of anaesthesia
- 1 February 1993
- journal article
- clinical trial
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 37 (2) , 176-180
- https://doi.org/10.1111/j.1399-6576.1993.tb03696.x
Abstract
The pharmacokinetics of sufentanil were studied in 56 surgical patients after an intravenous bolus of 2 μg kg‐1, in association with neurolept analgesia or volatile anaesthetics (halothane, enflurane and isoflurane). Plasma concentrations of sufentanil were measured by radioimmunoassay. The kinetics of sufentanil were comparable under neurolept analgesia and under anaesthesia with halothane, enflurane or isoflurane. The overall mean elimination half‐life was 182 min, Vd85 169 1 and the plasma clearance 910 ml min‐1. Except for the isoflurane subgroup, there was no significant correlation between half‐life, the volume of distribution or clearance with age (24–77 years) or body weight (45–95 kg).Keywords
This publication has 18 references indexed in Scilit:
- Comparison of Sufentanil and Fentanyl to Supplement N2O-Halothane Anesthesia for Total Hip Arthroplasty in Elderly PatientsAnesthesia & Analgesia, 1991
- Postoperative patient‐controlled analgesia with sufentanil: analgesic efficacy and minimum effective concentrationsActa Anaesthesiologica Scandinavica, 1991
- Sufentanil anaesthesia for major surgery: the multicentre Canadian clinical trialCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1989
- Pharmacokinetics of Sufentanil in Patients Undergoing Abdominal Aortic SurgeryAnesthesiology, 1989
- Sufentanil to supplement nitrous oxide in oxygen during balanced anaesthesiaAnaesthesia, 1988
- Midazolam-sufentanil anaesthesia for phaeochromocytoma resectionCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1988
- PHARMACOKINETICS OF SUFENTANIL IN THE ELDERLYAnesthesiology, 1987
- The Pharmacokinetics of Sufentanil in Surgical PatientsAnesthesiology, 1984