Effects of Hypophysectomy on Hypothalamic Obesity in CBA Mice.

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Abstract
Summary Lesions in the hypothalamus of female CBA mice were produced by administration of gold thioglucose (GTG). Hypophysectomy in groups of GTG lesioned mice (GTG/Hypex) and in normal mice (Hypex/Norm) was performed 4 days after GTG treatment. A significant increase in body weight and total body fat was seen only in the intact GTG-treated mice. Uptake of I-131 by the thyroid gland and adrenal weights were significantly decreased in the GTG/Hypex and Hypex/Norm mice. These data suggest that the pituitary may play an important role in production of hypothalamic obesity in mice.