Semi-Mechanized Simultaneous Synthesis of Multiple Oligonucleotide Fragments
- 1 January 1987
- journal article
- plenary lectures
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 6 (1) , 137-146
- https://doi.org/10.1080/07328318708056187
Abstract
A new strategy for the simultaneous synthesis of multiple oligonucleotides is described, which is based on asynchronous chain growth and use of a maximum number of support segments in each elongation. An approach to the mechanization of this strategy and applications to the preparation of gene fragments and sequentially variant probes are discussed.Keywords
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