Chrosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter
- 1 April 1993
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 91 (3) , 278-280
- https://doi.org/10.1007/bf00218272
Abstract
The neuronal Na+- and Cl--dependent transporter for the neurotransmitter noradrenaline (NA) is the primary target for the tricyclic antidepressant desipramine. The NA-transporter belongs to a new gene family of structurally related Na+- and Cl--dependent neurotransmitter transporters. In this study, the chromosomal localization for the gene encoding the human NA-transporter (h-NAT) was determined. By hybridization of a panel of somatic cell hybrids and by fluorescent in situ hybridization to metaphase chromosomes, the hNAT gene was localized on chromosome 16q12.2. In addition, evidence is presented for an intron-exon structure of the gene.Keywords
This publication has 11 references indexed in Scilit:
- Neurotransmitter transporters (plus): a promising new gene familyTrends in Neurosciences, 1992
- Report of the Second International Workshop on Human Chromosome 16 Mapping.1992
- Molecular-Biologic Basis of Manic-Depressive IllnessPharmacopsychiatry, 1992
- New Molecular Genetic Studies in the Affective DisordersPharmacopsychiatry, 1992
- Specific metaphase and interphase detection of the breakpoint region in 8q24 of burkitt lymphoma cells by triple‐color fluorescence in situ hybridizationGenes, Chromosomes and Cancer, 1992
- The gene for SP-40,40, human homolog of rat sulfated glycoprotein 2, rat clusterin, and rat testosterone-repressed prostate message 2, maps to chromosome 8Genomics, 1991
- Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporterNature, 1991
- Molecular genetics of the human Na+/glucose cotransporterJournal of Molecular Medicine, 1989
- Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA librariesHuman Genetics, 1988
- A general method for isolation of high molecular weight DNA from eukaryotesNucleic Acids Research, 1976