Ein statistisches Verfahren zur Ermittlung der Leistungs-Korrelation antibioticabildender Mikroorganismen im Labor- und Technikumsmaßstab

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Abstract
The antibiotic yields of industrial selectants must be checked at several steps of cultivation. The question arises whether the activities at the different levels of cultivation are correlated. The common coefficient of correlation cannot be used because repeated determinations of the yield at one selectant result in different values. In order to have only 1 fixed value/selectant, the mean value around which the observed values are varying was defined. These mean values cannot be observed. An adequate method of correlation similar to that in Guiard and Herrendoerfer was used. The method is demonstrated in 2 examples: with Streptomyces noursei for streptothricin titers in 20 ml- and 20 l-cultures and with Penicillium chrysogenum for potency indices in surface cultures and penicillin titers in 50 ml submerged cultures, respectively. In both cases the coefficients of correlation was above 0.7.

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