CARCINOGENIC EFFECT OF N-NITROSO(2-HYDROXYPROPYL)(2-OXOPROPYL)AMINE, A POSTULATED PROXIMATE PANCREATIC CARCINOGEN IN SYRIAN-HAMSTERS
- 1 January 1979
- journal article
- research article
- Vol. 39 (10) , 3828-3833
Abstract
N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) was a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine (BOP) and N-nitroso-2,6-dimethylmorpholine, and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular adenocarcinomas than did N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine. These neoplasms showed a great tendency for invasion and metastasis. HPOP induced tumors of the forestomach, liver, gallbladder, kidneys and vagina (as did BOP). HPOP [unlike BOP, but like N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine] led to tumor development in the nasal cavity, larynx, trachea, intestine, Harderian gland, lips and flank organ. The possible mechanisms of HPOP carcinogenicity are discussed.This publication has 14 references indexed in Scilit:
- A Potent Pancreatic Carcinogen in Syrian Hamsters: N-Nitrosobis(2-oxopropyl)amine2JNCI Journal of the National Cancer Institute, 1977
- Carcinogenic Effects of Diisopropanolnitrosamine in Sprague-Dawley RatsJNCI Journal of the National Cancer Institute, 1977
- Induction of Pancreatic Duct Carcinomas in the Syrian Hamster With 2,6-Dimethylnitrosomorpholine 2JNCI Journal of the National Cancer Institute, 1977
- Metabolism of the Pancreatic Carcinogens N -Nitroso-bis(2-oxopropyl)amine and N -Nitroso-bis(2-hydroxypropyl)amine in the Syrian Hamster 2JNCI Journal of the National Cancer Institute, 1976
- Spontaneous Tumors and Common Diseases in Two Colonies of Syrian Hamsters. III. Urogenital System and Endocrine Glands2JNCI Journal of the National Cancer Institute, 1976
- Spontaneous Tumors and Common Diseases in Two Colonies of Syrian Hamsters. I. Incidence and Sites2JNCI Journal of the National Cancer Institute, 1976
- Spontaneous Tumors and Common Diseases in Two Colonies of Syrian Hamsters. II. Respiratory Tract and Digestive System2JNCI Journal of the National Cancer Institute, 1976
- Spontaneous Tumors and Common Diseases in Two Colonies of Syrian Hamsters. IV. Vascular and Lymphatic Systems and Lesions of Other Sites2JNCI Journal of the National Cancer Institute, 1976
- "N-NITROSO-BIS(2-ACETOXYPROPYL)AMINE AS A FURTHER PANCREATIC CARCINOGEN IN SYRIAN GOLDEN-HAMSTERS1976
- Diabetogenic effects of N-nitrosomethylurea with special regard to species variationsExperimentelle Pathologie, 1975