Indirect enzyme-linked immunosorbent assay (Elisa) for detection of IgG antibodies against coxsackie B viruses

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Abstract
In tests for IgG antibodies against coxsackievirus B in man, the enzyme-linked immunosorbent assay (ELISA) was essentially group-specific and, unlike the type-specific neutralization test, usually failed to detect rises in antibody titer in paired, acute and convalescent sera. In rabbits immunized against coxsackievirus B, ELISA demonstrated group- and type-specific antibody responses. The lack of type specificity of ELISA in man is probably because repeated infection with enteroviruses, e.g., echoviruses, coxsackievirus A and coxsackievirus B, results in masking of the type-specific antibody response by group-specific antibody.

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