Tetracycline: Effect on Osteogenesis in vitro
- 20 August 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 149 (3686) , 870-872
- https://doi.org/10.1126/science.149.3686.870
Abstract
Tetracycline hydrochloride added to cultures of rudiments of embryonic bone in a concentration of 1 microgram per milliliter prevents mineralization of the bones and is found throughout the calcified zones. The inhibition is reversible; upon transfer of a treated culture to a normal medium, mineralization proceeds normally but maldeveloped bones result.Keywords
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