Prevention of Alcohol Withdrawal Seizures with Phenytoin in Rats
- 1 April 1981
- Vol. 22 (2) , 179-184
- https://doi.org/10.1111/j.1528-1157.1981.tb04099.x
Abstract
The efficacy of phenytoin in the prevention of alcohol withdrawal seizures was studied in rats. Phenytoin was administered together with and again 12 h after the last dose of chronic alcohol feeding. Protection against alcohol withdrawal seizures was not observed when phenytoin serum levels were below 8 .mu.g/ml. With phenytoin serum levels between 8-25 .mu.g/ml, only 1 of 32 rats had alcohol withdrawal seizures.Keywords
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