Kottamides A−D: Novel Bioactive Imidazolone-Containing Alkaloids from the New Zealand Ascidian Pycnoclavella kottae
- 18 June 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (15) , 5402-5404
- https://doi.org/10.1021/jo0201427
Abstract
Kottamides A−D (1−4), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from the New Zealand endemic ascidian Pycnoclavella kottae and structurally characterized using 15N natural abundance 2-D NMR in addition to standard spectroscopic methods. The kottamides exhibited anti-inflammatory and anti-metabolic activity as well as cytotoxicity toward tumor cell lines.Keywords
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