Persistent infection of rat insulinoma cells with Coxsackie B4 virus
- 1 March 1986
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 87 (1-2) , 143-150
- https://doi.org/10.1007/bf01310551
Abstract
Plaque purified Coxsackie B4 virus (CB4) caused a persistent infection of rat insulinoma (RIN) cells which lasted for the 70 day observation period. Infectious virus was produced and no cytopathic effect was observed. Indirect immunofluorescence and infectious center assays demonstrated that a majority of RIN cells were infected. Defective interfering particles were not demonstrated. Despite persistent infection, insulin synthesis by RIN cells was not altered.This publication has 21 references indexed in Scilit:
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