STIMULATED NEUTROPHIL LOCOMOTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 101  (10) , 509-513
Abstract
All leukocytes are capable of responding chemotactically (oriented locomotion) and chemokinetically (stimulated nondirected or random locomotion) to a variety of chemical agents. A brief review of the in vitro and in vivo methods of studying neutrophil movement and present knowledge of chemotactic factors is presented as well as a discussion on the mechanisms of stimulated movement. Two clinically important instances of defects in neutrophil movement, i.e., the Chediak-Higashi syndrome and a case of actin dysfunction, are described.