Correction of Leukocyte Function in Chediak-Higashi Syndrome by Ascorbate
- 4 November 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 295 (19) , 1041-1045
- https://doi.org/10.1056/nejm197611042951904
Abstract
Because ascorbate potentiates chemotaxis of normal leukocytes, we examined the effect of ascorbate on polymorphonuclear leukocytes from a patient with the Chediak-Higashi syndrome. Chemotactic migration was 104±16 leukocytes per 10 fields (mean±S.D.) initially and 258±44 (P7 polymorphonuclear leukocytes to 5.9, as compared to a control value of 3.1 ±1.4. The association of elevated cAMP and impaired function in the polymorphonuclear leukocytes of patients with the Chediak-Higashi syndrome may be related to abnormal microtubular assembly. (N Engl J Med 295:1041–1045, 1976)This publication has 23 references indexed in Scilit:
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