ENDOCRINE INFLUENCES ON SERUM ACID-ETHANOL SOLUBLE NON-SUPPRESSIBLE INSULIN-LIKE ACTIVITY (NSILA-S)

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Abstract
Serum levels of the acid-ethanol soluble component of nonsuppressible insulin-like activity (NSILA-S) were measured by bioassay in patient with hyperprolactinemia, hypothyroidism, thyrotoxicosis and diabetes mellitus, and in normal subjects administered prednisone, estrogens or androgens. Hyperprolactinemia per se did not influence serum NSILA-S; however when GH [growth hormone] was deficient prolactin hypersecretion may have maintained serum NSILA-S. Thyroid hormones, insulin and steroids did not appear to influence serum NSILA-S. Regulation of the serum concentration of NSILA-S is apparently not a common effector mechanism by which these hormones influence statural growth in man.

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