Increased antibodies against unfolded viral antigens in the elderly after influenza vaccination
Open Access
- 1 July 2007
- journal article
- Published by Wiley in Influenza and Other Respiratory Viruses
- Vol. 1 (4) , 147-156
- https://doi.org/10.1111/j.1750-2659.2007.00017.x
Abstract
Objective Our studies aimed to measure the quality of antibody response to influenza vaccines in the elderly. The frequency of significant rise in hemagglutination inhibition (HAI) titer in the elderly is low and although annual vaccination reduces morbidity and mortality, better correlates of vaccine efficacy in the elderly are needed.Keywords
This publication has 35 references indexed in Scilit:
- Vaccination strategies for an influenza pandemic.The Journal of Infectious Diseases, 2005
- Amount and avidity of serum antibodies against native glycoproteins and denatured virus after repeated influenza whole-virus vaccinationVaccine, 2005
- Detection of anti-H5 responses in human sera by HI using horse erythrocytes following MF59-adjuvanted influenza A/Duck/Singapore/97 vaccineVirus Research, 2004
- Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenzaThe Lancet, 2001
- The hemagglutination inhibition antibody responses to an inactivated influenza vaccine among healthy adults: with special reference to the prevaccination antibody and its interaction with ageVaccine, 1996
- Cross-reaction but no avidity change of the serum antibody response after influenza vaccinationVaccine, 1995
- Antibody response after influenza immunization with various vaccine doses: a double-blind, placebo-controlled, multi-centre, dose—response study in elderly nursing-home residents and young volunteersVaccine, 1993
- The conformational specificity of viral epitopesFEMS Microbiology Letters, 1992
- Safety and Immunogenicity of a 45-μg Supplemental Dose of Inactivated Split-Virus Influenza B Vaccine in the ElderlyThe Journal of Infectious Diseases, 1986
- Immunological Studies with the HA1 and HA2 Polypeptides of Influenza A Virus HaemagglutininPathobiology, 1978