Comparison of the Essential Cellular Functions of the Two murA Genes of Bacillus anthracis
Open Access
- 1 June 2008
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (6) , 2009-2013
- https://doi.org/10.1128/aac.01594-07
Abstract
Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis . Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of B. anthracis to this drug.Keywords
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