Pharmacokinetics of Trimethoprim (TMP) in Normal and Febrile Rabbits

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Abstract
The occurrence of fever in diverse disease states poses potential therapeutic problems if fever alters the pharmacokinetics of drug administered for treatment of the disease. The pharmacokinetics of trimethoprim (TMP), an antibacterial agent, were investigated in normal and febrile rabbits. The half-life of TMP in rabbits is about 40 min, and no differences were found between the half-life in normal and febrile rabbits. A significantly greater volume of distribution of TMP was found in febrile rabbits. Analysis according to the 2-compartment model showed that differences are due to a change in distribution of TMP towards peripheral compartments.