Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
- 8 December 2010
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 13 (2) , 280-283
- https://doi.org/10.1021/ol1026848
Abstract
A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.Keywords
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