Synthesis of porcine neuropeptide Y(NPY) in solution
- 1 April 1987
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 29 (4) , 533-544
- https://doi.org/10.1111/j.1399-3011.1987.tb02281.x
Abstract
The porcine neuropeptide Y (NPY), a 36-residue peptide amide, was synthesized by assembling six peptide fragments followed by thioanisole-mediated deprotection with trifluoromethanesulfonic acid in trifluoroacetic acid. β-Cycloheptyl aspartate, Asp(OChp), was employed to suppress base-catalyzed succinimide formation. When administered to dogs, the purified peptide (10μg/kg) caused prolonged increase of systemic arterial blood pressure and decreased pancreatic blood flow.Keywords
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