Sister chromatid exchange in PH1-positive chronic myelocytic leukemia
- 15 December 1979
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 24 (6) , 713-716
- https://doi.org/10.1002/ijc.2910240602
Abstract
The sister chromatid exchange (SCE) frequency in bone‐marrow cells of 12 untreated patients with chronic myelocytic leukemia (CML) was analysed and compared with the SCE frequency in bone‐marrow cells of nine healthy persons. In normal persons the SCE ranged from 3.64 to 5.15 per cell. In CML patients the SCE was significantly lower, ranging from 2.32 to 3.44 per cell. The differences found were unrelated to patients' age and contraction state of the chromosomes. It is suggested that the leukemic process could account for the low SCE rate.This publication has 14 references indexed in Scilit:
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