Evaluation of Circulating Antigens by a Sandwich Radioimmunoassay, and of Antibodies and Immune Complexes, in Schistosoma Mansoni-Infected African Parturients and Their Newborn Children *

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Abstract
Circulating Schistosoma mansoni soluble antigens (CSA), circulating anti-S. mansoni antibodies (CAb), and immune complexes (CIC) were studied in three groups of African patients living in the same area. The first two groups were composed of 26 S. mansoni-infected mothers and their 26 uninfected newborn children. The third group included 13 men and 10 non-pregnant women who were also infected with S. mansoni. CSA were quantified by using a solid phase sandwich radioimmunoassay, which was shown to be sensitive, reproducible, and S. mansoni-specific. CAb were studied by indirect hemagglutination. CIC evaluations were performed by using the Clq binding test. A high correlation was shown between the CSA levels in sera from infected mothers and from the umbilical cord of their newborn children, indicating that CSA are probably transferred through the placenta. CSA levels in mothers were significantly higher than in the third group, in which no difference was found between men and women. On the other hand, CAb and CIC were significantly higher in the third group than in the group of mothers, indicating that CSA levels may be modulated by the immune response of the host.