3-(2,6-Xylyl)-5-methylhydantoin—a metabolite or a metabonate of tocainide in rats?
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 11 (4) , 259-265
- https://doi.org/10.3109/00498258109045300
Abstract
1. G.l.c.-mass spectrometric analysis of urine extracts from rats dosed with tocainide (I) revealed the presence of a cyclic compound identified as 3-(2,6-xylyl)-5-methylhydantoin (IV) derived from tocainide. 2. Evidence indicates that IV is derived from a conjugate of tocainide (tocainide carbonyl O-β-D-glucuronide) (III) in humans. 3. Results of the present study indicate that in addition to being formed from a conjugate, IV is generated directly from tocainide in vivo in rats. Possible mechanisms for the formation of IV in rats in vivo are discussed.This publication has 11 references indexed in Scilit:
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